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Two different selenium-dependent iodothyronine deiodinases (DIOs type 1 and 2) can deiodinate T 4 , thus increasing circulating T 3 , while a third iodothyronine deiodinase (DIO type 3) can convert both T 3 and T 4 to inactive metabolites ( Figure 3 ) (10, 11)

Evaluation of 16s rrna gene sequencing for species and strain-level microbiome analysis

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Cells convert NAD+ precursors, like NMN, to NAD+, which contributes to reactions that generate cellular energy

This dual role makes it relevant to autoimmune conditions where microbial dysbiosis contributes to immune activation